It is now known that in addition to canonical Notch signaling where the activated Notch receptors can play tumor suppressive roles in some cancer types and oncogenic roles in others, non-canonical signaling is also active in some cell types and impacts signaling through phosphatidylinositol 3′ kinase (PI3K)/Akt, mTOR, NF-kB, and β-catenin (1–6). Here, MTOR is linked to cancer.