O’Sullivan et al. provide a complementary direction in “Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors.” Importantly, they broaden potential application with respect to tumor type, but focus on the molecular aspects that may help optimize PARP inhibitor use in a defined patient population. Here, PARP1 is linked to Hereditary breast and ovarian cancer syndrome.