There are three major families of transcription factors (TFs) that contribute to EMT and may also be general drivers of cancer (Figure 1B): (1) the zinc finger protein SNAIL family (SNAI1, SNAI2, and SNAI3) (32), (2) the basic Helix-Loop-Helix (bHLH) proteins TWIST1 and TWIST2 (33), and (3) the zinc-finger E-box binding (ZEB) family of TFs (34). The gene discussed is SNAI1; the disease is cancer.