FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) is a recently identified lncRNA which is located in chr7q31.32 on the opposite strand of gene FEZF1. Although its function in normal or cancer cells is still unknown, Chen et al. (2016) have recently identified significantly higher FEZF1-AS1 expression levels in tumor tissues of CRC patients compared to adjacent non-neoplastic mucosa tissues (P = 0.004). The gene discussed is FEZF1; the disease is cancer.