Correspondingly, several immediate early genes, such as Junb (Jun B Proto-Oncogene), Fos (FBJ Murine Osteosarcoma Viral Oncogene Homolog), Ier2 (Immediate Early Response 2), and Egr1 (Early Growth Response 1) contributed to the early gene response under both EGF and NGF stimulation, while members of the uPAR/Integrin signaling complex, such as Mmp13/10/3 (Matrix Metallopeptidase 13/10/3), Plat (Plasminogen Activator, Tissue) and Serpine1 (Serpin Peptidase Inhibitor, Clade E, Member 1) determined, among others, the separation of the NGF from the EGF trajectory. The gene discussed is JUNB; the disease is osteosarcoma.