SIGIRR and lupus nephritis: IL-1R8-deficient C57BL/6lpr/lpr mice also displayed and increased production of autoantibodies (anti-dsDNAIgG, anti-nucleosome, anti-Sm antigen, anti-snRNP, and rheumatoid factor) and presented a massive lymphoproliferative disorder, associated with enhanced autoimmune lung disease, lupus nephritis, and hypergammaglobulinemia, compared with IL-1R8-competent C57BL/6lpr/lpr controls (78).