IL-1R8 was shown to be a key player in sterile kidney diseases, by regulating TLR activation by nucleosomes and DAMPs, released during ischemic cell necrosis and associated with pathological conditions, such as lupus nephritis, postischemic acute renal failure, or kidney transplantation (78, 79, 86, 87) (Figure 4). The gene discussed is SIGIRR; the disease is lupus nephritis.