However, IL-1R8 deficiency in C57BL/6lpr/lpr mice, which develop delayed autoimmunity due to impaired Fas-induced apoptosis of autoreactive B and T cells, caused increased activation of DCs and B cells and production of pro-inflammatory cytokines (CCL2, IL-6, and IL-12p40) and B cell antiapoptotic mediators (Baff/BlyS and Bcl-2). The gene discussed is SIGIRR; the disease is Autoimmunity.