It is believed that tumor microenvironment releases various factors, such as GM-CSF, M-CSF, and VEGF, which may stimulate myelopoiesis, as well as the production of pro-inflammatory cytokines, such as IL-6, TNF, and IL-1β, and anti-microbial peptides S100A8 and S100A9 (9). This evidence concerns the gene IL6 and neoplasm.