Nefedova et al. subsequently demonstrated that conditioned medium from the murine CT26 colon carcinoma or C3 sarcoma cell lines could trigger Jak2/STAT3 signaling in hematopoietic progenitor cells (HPCs) and resulted in the abnormal accumulation of Gr1+/CD11b+ immature myeloid cells in an in vitro DC differentiation assay (148, 149). Here, STAT3 is linked to colon carcinoma.