Selective pressure to repress SOCS3 expression in STAT3-addicted tumors has been shown in cancers of the brain, esophagus, prostate, lung, bone marrow, colon, liver, cervix, and head/neck (199–206), which suggests that SOCS3 inhibition may not only promote tumor cell proliferation and metastasis but also drive tumor cell-mediated immunosuppression. The gene discussed is SOCS3; the disease is brain cancer.