BRAF and melanoma: DETS also effectively down-regulated β-catenin, MITF-M, Brn2 and BRAF, which strengthen the hypothesis that this compound is inhibiting the development and proliferation of melanoma cells by regulating WNT-β-catenin pathway, which converge in MITF-M, the master regulator of melanoma signaling and hence, may be the reason why the melanoma cell line A375 exhibited maximum sensitivity toward this compound.