miR-141 may be another miRNA of importance in DCM, since it was found to be significantly increased in the diabetic heart and its overexpression decreased the content of the inner mitochondrial membrane phosphate transporter, solute carrier family 25 member 3 (Slc25a3) in the mouse atrial cardiomyocyte cell line HL-1 (Baseler et al., 2012), suggesting that altered miR-141 expression may influence cardiac mitochondrial function and ATP generation (Baseler et al., 2012). Here, SLC25A3 is linked to familial dilated cardiomyopathy.