Many studies have demonstrated that ALDH2 overexpression or activation alleviates myocardial injury induced by I/R (Ma et al., 2011) diabetes, doxorubicin, acetaldehyde, and alcohol (Doser et al., 2009; Ma et al., 2010; Wang et al., 2011; Zhang et al., 2012). Here, ALDH2 is linked to diabetes mellitus.