In cerebral-I/R, 3MA and Atg7 knockdown to inhibit autophagy reinforced the brain and cell injury in the reperfusion phase, whereas the mitophagy inhibitor Mdivi-1 in the reperfusion phase and Park2 knockdown aggravated the ischemia-induced neuronal injury (Zhang et al., 2013). This evidence concerns the gene PRKN and ischemia.