SLC2A1 and Alzheimer disease: Further implication of the present work include pathological conditions associated with glucose deficiency, such as glucose transporter-1 deficiency syndrome in which the function of the main blood brain barrier glucose transporter GLUT1 is lost (Wang et al., 2005), as well as Alzheimer’s disease in which GLUT1 downregulation plays a significant role (Winkler et al., 2015).