Interestingly, the contribution of MAPT gene in motor impairment has been described in a large community-based cohort of neurologically healthy aging individuals (Shulman et al., 2014), where an association between H1 haplotype and mild parkinsonian signs, especially bradykinesia, has been observed without evidence of PD hallmark at pathological assessment. The gene discussed is MAPT; the disease is Parkinson disease.