YWHAQ and Alzheimer disease: In non-prion diseases, a host-derived protein is misfolded and persists in an aggregated form that may damage nearby cells [β-amyloid (Aβ) in AD, α-synuclein (α-syn) in PD, and tau-protein (τ) in tauopathies and AD (Costanzo and Zurzolo, 2013; Goedert, 2015)].