SHANK3 and fragile X-associated tremor/ataxia syndrome: Indeed, altered brain bioenergetics and those of the post-synaptic scaffolding protein Shank3 during perinatal periods may explain the abnormal behavior observed in KI mice later in life [12 and 24 weeks; (Van Dam et al., 2005; Hunsaker et al., 2009, 2012)], similar to the spatial processing defects observed in humans with FXTAS (Hunsaker et al., 2012).