Studies have shown that Zn deficiency in rodents results in anorexia (with about 50% of the body weight gained under physiological conditions), poor hair coat, scaly paws, and reproductive defects (Brody, 1999), none of which have been observed in either KI dams or pups, supporting the idea of a localized Zn homeostasis deficit related to the premutation (probably linked to the tissue expression of FMRP), rather than a generalized one. The gene discussed is FMR1; the disease is Anorexia.