Common and rare variants in the melanocortin-4 receptor MC4R locus 18q21.32 (rs74861148, rs483125, and rs11872992) or its promoter region were associated with triglycerides, obesity and T2DM (Bazzi et al., 2014; Katsuura-Kamano et al., 2014; Muller et al., 2014). This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.