IL6 and metabolic syndrome: Nuclear factor NF-κB also is, along with other factors (IL-6, cytokine signaling suppressor proteins, and endoplasmic reticular oxidative stress) (Tilg and Moschen, 2006), implicated in inflammation-induced T2DM (Cyphert et al., 2015), however, its own two gene loci (NFKB1 4q24 and NFKB2 10q24) have not been found associated with MetS themselves.