APOA5, APOC3, APOA1, and APOA4 loci are closely clustered in 11q23 (Nilsson et al., 2008), with SNPs rs2972146 near IRS1 locus shown associated with increased risk of T2DM, insulin resistance and hyperinsulinaemia (Teslovich et al., 2010); rs1042034 of APOB related to HTG as main lipoprotein of chylomicrons and lipid-rich particles (Teslovich et al., 2010), located on chromosome 2. This evidence concerns the gene APOB and type 2 diabetes mellitus.