Within these apolipoprotein genes, specific genetic factors for MetS (i.e., SNPs relevant for MetS risk) became evident in the Diabetic Heart Study (Adams et al., 2014), and others (Crosby et al., 2014; Gaio et al., 2014): rs3135506 (Ser19Trp, APOA5), rs651821 (5′UTR, APOA5), rs13832449 (splice donor, APOC3) (Crosby et al., 2014). The gene discussed is APOA5; the disease is metabolic syndrome.