The developmental precursor of adulthood MetS is seen in childhood ectopic lipid storage interfering with hepatic insulin signal transduction (Nelson and Bremer, 2010; Melka et al., 2013) with similar acceleration rates, and presumably resulting from epigenetic modifications and regulatory programming of obesity genes, and likely induced by nutrition-caused alterations of the gut microbiome (Remely et al., 2014b; Chang and Neu, 2015). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.