PPARG and obesity due to melanocortin 4 receptor deficiency: MiR-122 decrease was described central in hepatic fatty-acid and cholesterol synthesis rate, by reducing hepatosteatosis (Esau et al., 2006), together with miR-223 in obesity (Kilic et al., 2015), also with miR-425, miR-126, miR-16, miR-634 (Li et al., 2015), miR-519d, miR-27 and miR-519d for target PPARγ (McGregor and Choi, 2011), miR-26 triglyceride accumulation (Song et al., 2014).