TLR2 and metabolic syndrome: The exact mechanism of chronic low-level inflammation induced by action of adipose tissue is based on T-cell and macrophage accumulation (with expression of key adipogenic factors, PPARγ, CCAA-enhancer-binding protein C/ebpβ, insulin-like growth factor IGF, and toll-like receptors 2 and 4 TLR2/4s) in adipocytes (Sun et al., 2012; Ali et al., 2013; Lefterova et al., 2014), and a lack of vagally mediated downregulation of the “inflammatory response” in MetS (Pavlov and Tracey, 2012; Figure 1).