Relation of CpG islands with fetal growth and greater birth weight, with maternal stress, indicating that greater stress is related to gene activity. Similarly, prenatal maternal strain associated with less methylation to provide greater postnatal gene expression, with sex-specific transcriptional regulation. Hypermethylation in HSD11B2 promoter is related to hypertension and atherosclerosis. Here, HSD11B2 is linked to atherosclerosis.