Nevertheless, the advantage in terms of survival in ERCC1- patients was confirmed in all subgroups, in lymph nodes-limited disease (PFS: 12 vs. 4 months, HR 0.10, 95% CI 0.004-2.56, p< .0001; OS: 22 vs. 8 months; HR 0.16, 95% CI 0.01–2.05, p=.0006), in liver-limited disease (PFS: 11 vs. 5 months, HR 0.46, 95% CI 0.16-1.36, p= .08; OS: 14 vs. 8 months; HR 0.39, 95% CI 0.13–1.17, p= .034) and in pluri-metastatic tumors (PFS: 10 vs. 4 months, HR 0.24, 95% CI 0.11-0.55, p< .0001; OS: 14 vs. 7 months; HR 0.25, 95% CI 0.11–0.57, p<.0001). This evidence concerns the gene ERCC1 and metastatic neoplasm.