Kaplan-Meier survival curves of 61 patients who adopted CHOP/CHOPE regiment showed that DLBCL patients with either positive PD-L1 or p-AKT expression corresponded with a significantly shorter 3 years OS (P=0.018, P=0.033, Figure 2A and 2B) and 5 years OS (P=0.012, P=0.028, Figure 2D and 2E) compared to patients with negative PD-L1 or p-AKT expression. The gene discussed is CD274; the disease is diffuse large B-cell lymphoma.