Kaplan-Meier survival curves of 39 patients who adopted R-CHOP regiment showed that DLBCL patients with positive PD-L1 expression had a significantly shorter 3 years OS (P=0.028, Figure 3A), but not 5 years OS (P=0.061, Figure 3D), compared to patients with negative PD-L1 expression. This evidence concerns the gene CD274 and diffuse large B-cell lymphoma.