TP53 and cancer: At last, when these studies were stratified by quality score, a increased cancer risk associated with TP53 rs78378222 polymorphism was observed in both high quality (OR = 1.406, 95% CI 1.192–1.658, P < 0.001) and low quality group (OR = 2.949, 95% CI = 1.839–4.728, P < 0.001) (Table 2).