The stratified analysis by cancer type revealed that TP53 rs78378222 C allele was significantly associated with an increased risk of nervous system cancer (OR = 2.567, 95% CI = 2.046-3.222, P < 0.001), skin cancer (OR = 1.424, 95% CI = 1.002–2.025, P = 0.049), and other cancer (OR = 1.422, 95% CI = 1.176–1.721, P < 0.001) (Figure 3). The gene discussed is TP53; the disease is cancer.