CD38 and anemia (phenotype): In the presented study we have pointed that hemoglobin level is in correlation with RDW, but other CLL parameters such as ZAP-70 and CD38 expression have also changed according to RDW stratification It should be noted that anemia in neoplastic diseases like CLL does not simply reflect a decrease in peripheral blood erythrocytes number but may be a parameter of inflammation status as well, being associated with impaired iron release from reticuloendothelial macrophages [20].