This is consistent with the established roles of EMT during ESCC progression, since reduced E-cadherin [16–20] with increased N-cadherin [21, 22] and vimentin [23, 24] expression would reduce cell adhesion, increase cell mobility, and ultimately enhance cell invasiveness and metastasis to form advanced stage tumors. The gene discussed is VIM; the disease is esophageal squamous cell carcinoma.