This is consistent with the established roles of EMT during ESCC progression, since reduced E-cadherin [16–20] with increased N-cadherin [21, 22] and vimentin [23, 24] expression would reduce cell adhesion, increase cell mobility, and ultimately enhance cell invasiveness and metastasis to form advanced stage tumors. Here, CDH2 is linked to esophageal squamous cell carcinoma.