In the case of the high HER2 expressing tumor cell line (SKOV-3 > 106 receptors/cell), predicted uptake approaches the maximum value of 14–15%ID/g at binding potential (BP = target concentration relative to dissociation constant, [T]/Kd) values of 50 or greater (Kd < 20 nM) for these slowly internalized affibodies. This evidence concerns the gene ERBB2 and neoplasm.