However, cisplatin treatment significantly inhibited the secretion of IL-10 and induced the secretion of TNF-α and IFN-γ in the C57BL/7 mice with miR-424(322)-overexpressing tumours, which suggests that miR-424(322) enhanced the efficacy of chemotherapy by reducing the secretion of regulatory cytokines. The gene discussed is IL10; the disease is neoplasm.