TP53 and colorectal carcinoma: However, common genetic features of CRC have emerged including mutations affecting APC [2], activating mutations of KRAS or BRAF oncogenes [3], deletions of the 18q [4] and 17p [5] chromosomal regions, microsatellite instability (MSI) [6] with deleterious mutations affecting the tumor suppressor genes TP53 [7].