In 2003 Kroes et al. [9] related EDS to mutations in COL3A1, the following year Mizuguchi et al. [10] associated TGFBR2 mutations with marfanoid phenotype, and finally in 2005 Loeys and colleagues distinguished and characterized LDS as the separate entity caused by defects in the TGFBR1 and TGFBR2 genes [11]. The gene discussed is TGFBR2; the disease is Ehlers-Danlos syndrome.