Disruption of the ligation between CD40 and CD40L either by small interfering RNA or by a blocking anti-CD40 antibody inhibited foam cell formation in response to sCD40L [160].Moreover, a meta-analysis of the rs1883832 CD40 SNP has shown a correlation between the C allele of this SNP and acute coronary syndrome in a Chinese population [157]. The gene discussed is CD40; the disease is acute coronary syndrome.