PLOD2 and osteogenesis imperfecta: Notably, several studies have failed to show any abnormalities in the biosynthesis of collagen 1 and 2 as it can be noted in OI individuals [4], but recent reports have shown that mutations in other genes, like PLOD2 and FKPB10, can result in both BS and Autosomal-Recessive OI (AR-OI) phenotypes with variable degrees of bone fragility and joint contractures [5], suggesting the necessity for reassessing the current classification of OI.