LEP and obesity due to melanocortin 4 receptor deficiency: Other studies showing: 1) protective effect of leptin against the later obesity via changes in promoter methylation of some genes, including the hypothalamic Pomc [73] and 2) histone deacetylation and DNA methylation of Kiss1 in AVPV/PeN contributing to sex-specific differences in the neuronal cell number [74] give a rationale for further testing of our hypothesis.