Furthermore, Western blot and immunofluorescence results demonstrated that the expression of bone morphogenetic protein-7(BMP-7), a protective molecule in renal inflammation, was clearly up-regulated in AKI models with the addition of GA in vivo and 18βGA in vitro while siRNA BMP-7 could reduce the 18βGA inhibitory effect on apoptosis. Here, BMP7 is linked to acute kidney injury.