In contrast, the proportion of circulating topo-I-specific CD4+ T cells was quantitatively associated with the progression of lung fibrosis as defined by the loss of lung volumes within the year preceding the test date (Pearson r = 0.721, p = 0.002) (Fig. 5c) or during the subsequent one (Pearson r = 0.764, p = 0.017) (Fig. 5d). The gene discussed is CD4; the disease is pulmonary fibrosis.