For example, recent study found increased expression of CCL2 mRNA in human gallbladder adenocarcinoma than those in human chronic cholecystitis [17]; Exogenous CCL2 expression by murine colon adenocarcinoma cells have been found to promote its lung metastases through promoting neovascularization [18, 19]. This evidence concerns the gene CCL2 and colon adenocarcinoma.