VIM and thyroid tumor: In line with these findings, we found that elevated vimentin in thyroid tumors of HFD-ThrbPV/PVPten+/− mice was inhibited by metformin, thereby decreasing the extent of EMT (Figure 4A-I, panel c, lanes 10-12 versus lanes 4-6; also quantitative data: Figure 4A-II-b, bar 4 versus bar 3) to suppress cell invasion.