AKT1 and cancer: RAN, a GTP-binding nuclear protein, member of small GTPase superfamily, is involved in several important cellular processes, the best known being nucleocytoplasmic transportation [30], Which regulates many cancer-related signaling pathways such as PI3K/Akt/mTORC1 and MEK/ERK, and plays an important role in cancer cell survival and progression [31, 32].