TRIM29 expression in pancreatic cancer cells is 20 times higher than that in normal pancreas epithelial cells, overexpression of TRIM29 in pancreatic cancer lines promoted cell growth in vitro and metastatic activity in vivo stemming from stimulation of Wnt/β- Catenin/TCF signaling through TRIM29 binding to Dvl-2, a Wnt pathway activator downstream of the Frizzled receptor [19]. The gene discussed is HNF4A; the disease is familial pancreatic carcinoma.