In addition, infiltrating immune cells are usually observed in tumor lesions: some of these cells are related to a cytotoxic effector activity against tumor cells (e.g. CD8+ T cells, or Natural Killer cells) but other populations are involved in the stimulation of tumor progression (e.g. pro-tumoral macrophages M2); moreover, a gene expression profile correlated with inflammation was described in different tumors [104–105]. Here, CD8A is linked to neoplasm.