Compared with early staged DN, renal fibrosis was worsened (Figure 10C and 10D) and renal function dropped as demonstrated by increased level of serum BUN, creatinine, β2-microglobulin, 24 hour proteinuria and UACR and decreased estimated glomerular filtration rate (eGFR) (Table 2). The gene discussed is HLA-G; the disease is liver dysplastic nodule.