SIRT1 and colorectal carcinoma: Since our previous studies showed that SIRT1 was significantly overexpressed in CRC [23], and the results obtained by the application of the online prediction software TargetScan 6.2, DIANA LAB, and PicTar all indicated the presence of miRNA responsive elements within the 3′UTR of SIRT1 as putative miR-199b targets (Figure 5A), we further evaluated whether SIRT1 was the direct target of miR-199b.