STAT3 and cancer: Our team demonstrated that B7-H3 could active the Jak2-STAT3 signaling pathway to up-regulate the expression of the anti-apoptotic Bcl-2 family members Bcl-2 and Bcl-xl and down-regulate the expression of the pro-apoptotic protein Bax to inhibit cancer cell apoptosis and cause drug resistance in cancer cells [28].