When compared to known gene sets from the Molecular Signature Database (MSigDB) [59] in an unbiased way, the top hit was for a set of genes (VERHAAK_AML_WITH_NPM1_MUTATED_DN; p-value: 2 × 10−86) that are down-regulated by NPM1 (nuclephosmin 1) mutation in AML (S1 File). The gene discussed is NPM1; the disease is acute myeloid leukemia.