Although the role of NFKBIB in lung cancer has not been studied extensively, its related family member NFKBIA is known to be a silencer in non-small-cell lung cancer patients with no smoking history, suggesting that it could play some role in LUAD that arises through inherent genetic influences, or environmental insults other than smoking [66]. The gene discussed is NFKBIA; the disease is non-small cell lung carcinoma.