Among these were key regulators of hematopoietic system development such as KIT, HOXA3, HOXA9, HOXB3 (with the latter homeobox genes also implicated in AML etiology), as well as FLT3 which plays a major role in AML disease biology, with its mutation and constitutive activation conferring significantly worse outcomes for patients [61]. Here, HOXA9 is linked to acute myeloid leukemia.