CA9 and renal cell carcinoma: For the anti-CAIX CAR T cells secreting anti-PD-L1 IgGs, a unique differential effect was seen for the IgG1 isoform, which was able to induce around 60% of ADCC in CAIX+/PD-L1+ RCC cells when incubated with natural killer cells (NK) (Figure 2G).