The anti-PD-L1 mAb used for IHC [21] recognizes a different domain than the anti-PD-L1 mAb secreted by the lentivirus, and the decrease in PD-L1 expression observed in the groups treated with anti-PD-L1-secreting CAR T cells is probably due to endocytosis or tumor cell death. This evidence concerns the gene CD274 and neoplasm.