Moreover, we demonstrated that HVJ-E RNA fragment-dependent activation of the cytoplasmic RNA receptor retinoic acid-inducible gene-I (RIG-I) and mitochondrial antiviral signaling protein (MAVS) activates the upregulation of TRAIL and Noxa, which enables HVJ-E-mediated cancer-selective apoptosis [26]. Here, MAVS is linked to cancer.