USP22 has been shown to promote the proliferation of human non-small cell lung cancer cell H1129 and human bladder cancer cell EJ by facilitating cell cycle progression, which was supported by the observed G1 phase arrest and concomitant reduction in the S and G2/M phase when USP22 was depleted [7, 15]. The gene discussed is USP22; the disease is urinary bladder carcinoma.