Recently, Rekhtman et al. screened 95 biomarker-verified SqCLC and reported that EGFR/KRAS mutations do not occur in pure SqCLC, occasional detection of these mutations in samples diagnosed as “SqCLC” is due to the diagnosis of adenosquamous carcinoma (AD-SQC) and adenocarcinoma [18]. Here, KRAS is linked to adenosquamous carcinoma.