HMGB1 and neoplasm: For example, MIA expression is enhanced by high-mobility group box 1 (HMGB1) nuclear factor kappa B (NFkB) p65 complexes that bind to the MIA promoter region, thus promoting tumor progression, nodal metastasis, a worse prognosis, angiogenesis, and lymphangiogenesis through the upregulation of vascular endothelial growth factor (VEGF)-A, VEGF-C, and VEGF-D expression [17, 18].