TNKS have been reported to influence other processes involved in growth control in addition to Wnt signaling including regulation of telomere length (TRF1), spindle polarity (NUMA), DNA repair (DNAPK), metabolism (GLUT4) and tumor suppression (PTEN) through paryslation-mediated degradation or stabilization [45, 48]. This evidence concerns the gene TNKS and neoplasm.