However, the refractory nature of tumors such as mesothelioma to current treatments and the identification of angiomotin, whose stabilization by TNKS inhibitors specifically antagonizes the proliferation of such tumor cells, argues that approaches aimed at angiomotin stabilization could eventually lead to new targeted therapies for the increasing array of Hippo pathway deregulated tumors for which there are as yet no effective therapies. Here, TNKS is linked to mesothelioma.