The combination of RES and CF decreased the number of angina episodes and thereby improved the quality of life of the patients; the N-terminal prohormone of brain natriuretic peptide (NT-proBNP), a biomarker of heart failure, was significantly lowered by RES (59.7% decrease after 60 days) and by CF (52.6% after 60 days), their combination being the most effective (65.5% after 60 days). The gene discussed is NPPB; the disease is angina pectoris.