For example, the accumulation of osteopontin (Figure 6a), uteroglobin, calreticulin, CD59 glycoprotein, vascular adhesion molecule-1 (VCAM1) (Figure 6b), prostaglandin-H2 D-isomerase, superoxide dismutase (Figure 6c), and guanylin was detected only in the most advanced CKD stages. This evidence concerns the gene SPP1 and chronic kidney disease.