CNN1 and pulmonary arterial hypertension: Furthermore, we demonstrate that ectopic increases in miR-214 in control hPASMC mimics a PAH phenotype, characterized by suppression of the MEF2C-MYOCD-LMOD1 axis, as well as other SMC-specific contractile proteins, including MYH11, smoothelin and CNN1 and, increased hPASMC proliferation and cell cycle progression (Figs 4 and 6).