Based on a strong association of miR-214 with MEF2C and contractile protein LMOD1 in PAH, and exact complementarity of the miR in their 3’UTR regions, we tested miR-214’s potential synergistic role in suppressing MEF2C (and attendant downstream contractile proteins, Fig 8) and LMOD1. Here, MEF2C is linked to pulmonary arterial hypertension.