A representative illustration of the prostate areas extracted for analysis (a ‘tissue map’) of the prostatectomy tissue, the pathological status of each area (tumor or benign) and the TMPRSS2:ERG status of each area extracted is shown in Fig 1 demonstrating the extensive amount of tissue analyzed (see S1 Fig for the ‘tissue maps’ of all 21 patients). Here, ERG is linked to neoplasm.