Although limited in sample size with only 3 TMPRSS2:ERG positive tissue samples being TMPRSS2:ERG negative in urinary exoRNA, versus 13 that had exact correlation with positive expression in both tissue and urinary EVs, data revealed that TMPRSS2:ERG expression in tumor tissue was ~98 fold higher (P = 0.009) in patients with detectable urinary exoRNA TMPRSS2:ERG expression. The gene discussed is ERG; the disease is neoplasm.