High-mobility group AT-hook 2 (HMGA2) and Collagen Triple Helix Repeat Containing 1 (CTHRC1), the top two up-regulated genes (according to our data) with log2 fold changes greater than 6, have been reported in the literature to be overly expressed in several cancer types and to be related to tumor prognosis [23–26]. This evidence concerns the gene CTHRC1 and cancer.