SLC7A11 and nonpapillary renal cell carcinoma: In order to evaluate the SLC7A11 in other subtypes of kidney cancer, we have used the TCGA data [48, 49] and found that SLC7A11 significant upregulation in RCC subtypes ccRCC, chromophobe RCC (chRCC) and papillary RCC (pRCC) (Figure 6) and the upregulation was associated with significant poor survival of patients (Figure 5c, 5d, 5e).