As for different TAM polarizations in tumor islet, high density of CD68+HLA-DR+ M1 TAMs was also associated with better OS (HR = 0.23, 95% CI = 0.18 ~ 0.29, P < 0.00001; I2 = 0%, P = 0.49; Figure 3B), while islet CD68+CD163+ M2 density was not associated with OS (HR = 0.83, 95% CI = 0.43 ~ 1.579, P = 0.56; I2 = 71%, P = 0.03; Figure 3C). The gene discussed is CD163; the disease is neoplasm.